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NX-2127 is a unique potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells
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Chemical. CAS 209783-80-2. Formula C21H20N4O3. MW 376.4. HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.
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Chemical. CAS 152121-30-7. Formula C20H14FN3O. MW 331.3. Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer
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Chemical. CAS 94367-21-2. Formula C40H53N5O10. MW 763.9. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases. Extinction 380nm. Emission 460 nm. This substrate is useful for inhibitor screening and kinetic analysis.
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Chemical. CAS 133429-58-0. Formula C29H39N3O5. MW 509.7. Reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC.
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